Seminar | March 24 | 2-3 p.m. | 277 Cory Hall
Prof. Masaru Tanaka, Kyushu University, Institute for Materials Chemistry and Engineering
Berkeley Nanosciences and Nanoengineering Institute
Water molecules play a crucial role in bio-interfacial interactions, including protein adsorption/desorption and cell adhesion behavior. To understand the role of water in the interaction of proteins and cells at biological interfaces, it is important to compare the states of hydration water with various physicochemical properties of hydrated biomaterials.
Here, we present the fundamental concepts for determining the interactions of proteins and cells with hydrated materials along with selected examples corresponding to our recent studies, for example, poly(2-methoxyethyl acrylate) (PMEA), PMEA derivatives, zwitterionic polymers, poly(ethylene glycol), and poly(2-oxazoline)s, and other biomaterials including biomolecules/polymers (DNA, RNA, proteins, and polysaccharides).
The states of water were analyzed by differential scanning calorimetry, in situ attenuated total reflection infrared spectroscopy, and surface force measurements. We found that intermediate water which is loosely bound to a biomaterial, is a useful indicator of the biocompatibility of material surfaces. This finding on intermediate water provides novel insights and helps develop novel experimental models for understanding protein adsorption in a wide range of materials, such as those used in biomedical applications.
*******
Masaru Tanaka did his PhD at Hokkaido and after serving as Nano faculty there and at Tohoku and Yamagata joined Kyushu in 2015. He has over 200 papers and 250 patents involving biomedical devices. Many national awards for soft materials engineering as well.
victorr@eecs.berkeley.edu, 510-643-6681
Avi Rosenzweig, victorr@eecs.berkeley.edu, 510-643-6681
