The Clelland lab is a translational neuroscience lab focused on developing novel CRISPR genome therapies for patients with fatal neurodegenerative diseases such as dementia and ALS.
We (the Clelland lab) are working to cure genetic neurologic diseases, including dementia and ALS. We develop CRISPR gene therapies for mutations that cause these devastating and fatal diseases. One major challenge we have is finding pairs of gRNAs that target specific alleles (or copies) a gene that we can exploit for gene editing. To do this we need to know the frequency and location of single nucleotide polymorphisms (SNPs) within a patient's genome and across many genomes; and to pair that information with sequences that can be targeted by gRNAs. Our project is based on large publicly available genomic data sets, patient genomic data sets and building interfaces that biologist can use for cutting edge research. We are seeking motivated and creative people to join our team. CS and/or data science preferred.
